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As a specialist in diet and diabetes, he has done clinical trials for three decades for all the big pharmaceutical companies, including work on a diabetes drug for Lilly and an insulin inhaler for Pfizer Calmly, matter-of-factly, he unlocked the second room Along one entire wall, maybe 12 feet long, three glass-doored wooden bookshelves were filled with blue, white, and green loose-leaf binders Each binder, one to three inches thick, was a patient; each color was a trial Then we walked across the hall to a small computer lab In bookshelves scattered around the room were sets of four-inch-thick binders containing the protocols and rules for various trials There were plenty more from older trials, stored in a warehouse, because the FDA requires scientists to keep their records for five years after a study ends, and inspectors may visit the trial sites for an audit at any time.

Here is the and M parameters for the code, where M = N - computation of the pseudoposteriors: K , maxcolweight and maxrowweight represent / / Vertical step: the maximum weight of the columns (typically 3) and / / Work across the columns.

It is easy to make fun of the FDA s rules for submitting paperwork Its instructions can go into details as picayune as how to number the various tables, how wide to make the margins, and what type font to use A fully paginated document with a table of contents, appropriate indices, appendices, cross references, and tabs differentiating sections is recommended.

(5.17)

Certificate Standard, and the Online Certificate Status Protocol (OCSP). PKI enables many secure applications and protocols, including SSL, S/MIME, SET, and IPSec. Integrating our applications with PKI technology requires some discipline on our part.

Our last example demonstrates a forms solution that allows you to put a very large number of fields on a single screen, without using paging. Listing 2.3 shows how to make a form using a CommandBands control with moveable, resizeable bands.

Equation (5.43) does not provide a very explicit formula for computing I,. manipulated into more useful forms. Reciprocating both sides we obtain (1 - q z ) = However, it can be

The kinds of mistakes that are chronicled in this book are real-world experiences we have faced as developers working with these tools the kinds of experiences that cause actual delays in schedule, or allow major bugs to get into the users hands, or led to lots of rewrites in maintenance because the code was so hard to change or understand. The Jakarta open source community has exploded over the last couple of years with insanely popular and useful projects, including the ones covered here: Ant, Cactus, and Struts. Given the relative newness of the technology, many developers are inexperienced with these tools and are getting trapped by the same pitfalls over and over. This book is an attempt to capture some of the most common pitfalls and the means to arrive at solutions. It is our hope that you will be saved the frustration of being trapped by the same pitfalls that have trapped us. Even if you are an experienced developer, that doesn t mean that you can t get something out of this book. After all, just because everyone uses a technology does not always mean that they use it correctly. It takes time for common mindshare to develop around a concept and for common problems and solutions to become well known. For example, early adoptors of Ant, Cactus, and Struts suffered from poor documentation. Over time, the documentation has become very good for all three of these Jakarta projects, but some developers are still building bad code out of habit. What we provide here, therefore, is not an introductory Ants, Cactus, or Struts book; it s a way to improve code incrementally and to find out about the nooks and crannies that could make your code hard to maintain or perform poorly. In